Sacco is a Professor of Economy of Culture at IULM University in Milan, Scientific Director at the Campus Foundation in Lucca and Visiting Professor in Applied Humanities at Harvard University. 

He has published more than 200 papers in international journals regarding topics such as culture-based development, cultural policies, cultural and creative industries and game theory applied to cultural evolution. He has provided consulting services to public administration offices, institutions and private companies at international level, as well as being invited on a regular basis as keynote speaker to major international conferences on topics including cultural policies and the economy of culture. He is a member of the Commission for the Economy of Culture and Museums at the ministry for Cultural Heritage and Activities, of the European Expert Network on Culture (EENC), of the European House of Culture and of the Advisory Group at the European Foundation. 

He writes articles for Il Sole 24 Ore, Flash Art, Artribune and Domus.

Sacco studies and describes the value of culture in various industries, starting from the business sector, focusing on the relevance it has in contemporary corporate processes and in terms of social accountability. He addresses public administration offices on topics such as enhancing and managing artistic-cultural assets and museums, large cultural events and territorial development, territorial planning, culture and urban transformation. Thanks to his international experiences, he is also knowledgeable about topics including European cultural policies and programmes, the global scenarios of cultural and creative production and the emerging cultural scenarios in the Middle and Far East, more specifically as regards intercultural dialogue and social inclusion. He is also an expert on the contemporary art market.