Mannocchi has reported from Iraq, Libya, Lebanon, Syria, Tunisia, Egypt, Yemen, Afghanistan, and has won many awards for journalism including the Premio Ischia, Premio Giustolisi and Premiolino 2016. She was a finalist for Kurt Shork Journalism Award 2017, the Fetisov Award for Journalism in 2019, Premio Luchetta, Premio Ilaria Alpi, and the DIG Award.

Along with photographer Alessio Romenzi, she directed the documentary ISIS, Tomorrow, which was presented at the 75th Venice International Film Festival.

Her books include: Porti ciascuno la sua colpa [To Each His Own Guilt] (Laterza, 2019), Libia [Libya] with illustrator Gianluca Costantini for (INK Mondadori, 2019), Se chiudo gli occhi [If I Close My Eyes], with the illiustrator Diala Brisly (RoundRobin, 2018). With Einaudi in 2019 she published Io Khaled vendo uomini e sono innocente [I Khaled sell humans and yet am innocent], which won the Premio Estense, and in 2021, Bianco è il colore del danno [White is the color of damage]. Her most recent book is Lo sguardo oltre il confine. Dall’Ucraina all’Afghanistan, i conflitti di oggi raccontati ai ragazzi [A Look Across the Border: From Ukraine to Afghanistan, Today’s Conflicts Told to Children] (De Agostini, 2022).